Polich 2016 updating p300

Posted by / 10-Mar-2020 08:13

Like MMN, P300 is usually assessed through variations of the oddball paradigm; however, whereas the former assesses preattentive cognitive information processing, P300 generation relies on a subject’s active attention to task demands ().Moreover, although MMN reflects a sensory-based mismatch detection process, theoretical accounts of P300 posit that P300 is generated through an attention-driven comparison process in working memory ().

P300 amplitudes demonstrate high test–retest reliability in both control subjects and schizophrenia patients ().P300 is smaller in men and has reduced amplitude and prolonged latency in the elderly.P300 amplitude is also sensitive to level of fatigue, tonic exercise, and acute nicotine use (for review of biological and cognitive determinants of P300, see ).In chronic schizophrenia patients, it has been shown that the magnitude of P300 deficits is correlated with reduced gray matter in the left posterior superior temporal gyrus (STG), and the same association has been observed in first-episode patients with schizophrenia, but not in those with affective psychosis ().These findings are in agreement with EEG source localization studies associating P300 abnormalities deficits in schizophrenia with broad reduced activity in left hemispheric regions, including the prefrontal cortex, posterior cingulum, and temporal lobe ().

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A common experimental procedure entails subjects physically or mentally responding to an infrequent stimulus designated the “target,” which is randomly embedded in a background of “standard” stimuli.

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